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Effects of Nrf2 silencing on oxidative stress‐associated intestinal carcinogenesis in mice
To assess the risk of colorectal cancer in humans with inactivation of NRF2, Nrf2‐proficient (Nrf2 (+/+)) and ‐deficient (Nrf2 (−/−)) mice were exposed to potassium bromate (KBrO(3)) at concentrations of 750 or 1500 ppm for 52 weeks. Neoplastic proliferative lesions were observed in the small intest...
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| Publicado en: | Cancer Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4924381/ https://ncbi.nlm.nih.gov/pubmed/26899729 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.672 |
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