Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin

Oxidative stress is well known as a key factor of chemical carcinogenesis. However, the actual role of oxidative stress in carcinogenesis, such as oxidative stress-related in vivo mutagenicity, remains unclear. It has been reported that 8-hydroxydeoxyguanosine (8-OHdG), an oxidized DNA lesion, might...

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Detalhes bibliográficos
Publicado no:J Toxicol Pathol
Main Authors: Tsuchiya, Takuma, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Yokoo, Yuh, Nishikawa, Akiyoshi, Yanai, Tokuma, Umemura, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society of Toxicologic Pathology 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077160/
https://ncbi.nlm.nih.gov/pubmed/30093787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2018-0024
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