Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in Nrf2-deficient gpt delta mice

Despite its antimicrobial activity, nitrofurantoin (NFT) is a renal carcinogen in rats. Oxidative stress induced by reduction of the nitro group of NFT may contribute to its genotoxicity. This is supported by our recent results indicating that the structure of the nitrofuran plays a key role in NFT-...

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Detalhes bibliográficos
Publicado no:J Toxicol Pathol
Main Authors: Tsuchiya, Takuma, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Yokoo, Yuh, Nishikawa, Akiyoshi, Yanai, Tokuma, Umemura, Takashi
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society of Toxicologic Pathology 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077154/
https://ncbi.nlm.nih.gov/pubmed/30093786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2018-0014
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