Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity

In this study, the potential for development of an animal model (GPG46) capable of rapidly detecting chemical carcinogenicity and the underlying mechanisms of action were examined in gpt delta rats using a reporter gene assay to detect mutations and a medium-term rat liver bioassay to detect tumor p...

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Dettagli Bibliografici
Autori principali: Matsushita, Kohei, Kijima, Aki, Ishii, Yuji, Takasu, Shinji, Jin, Meilan, Kuroda, Ken, Kawaguchi, Hiroaki, Miyoshi, Noriaki, Nohmi, Takehiko, Ogawa, Kumiko, Umemura, Takashi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Japanese Society of Toxicologic Pathology 2013
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620210/
https://ncbi.nlm.nih.gov/pubmed/23723564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.26.19
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