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Eukaryotic Genome Instability in Light of Asymmetric DNA Replication

The eukaryotic nuclear genome is replicated asymmetrically, with the leading strand replicated continuously and the lagging strand replicated as discontinuous Okazaki fragments that are subsequently joined. Both strands are replicated with high fidelity, but the processes used to achieve high fideli...

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Bibliografiska uppgifter
I publikationen:Crit Rev Biochem Mol Biol
Huvudupphovsmän: Lujan, Scott A., Williams, Jessica S., Kunkel, Thomas A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922258/
https://ncbi.nlm.nih.gov/pubmed/26822554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2015.1117055
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