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Genome-wide model for the normal eukaryotic DNA replication fork

To investigate DNA replication enzymology across the nuclear genome of budding yeast, deep sequencing was used to establish the pattern of uncorrected replication errors generated by an asymmetric mutator variant of DNA polymerase δ (Pol δ). Sequencing of 16 genomes identified 1,206-bp substitutions...

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Bibliografische gegevens
Hoofdauteurs: Larrea, Andres A., Lujan, Scott A., McElhinny, Stephanie A. Nick, Mieczkowski, Piotr A., Resnick, Michael A., Gordenin, Dmitry A., Kunkel, Thomas A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955150/
https://ncbi.nlm.nih.gov/pubmed/20876092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010178107
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