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Genome-wide model for the normal eukaryotic DNA replication fork

To investigate DNA replication enzymology across the nuclear genome of budding yeast, deep sequencing was used to establish the pattern of uncorrected replication errors generated by an asymmetric mutator variant of DNA polymerase δ (Pol δ). Sequencing of 16 genomes identified 1,206-bp substitutions...

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Autores principales: Larrea, Andres A., Lujan, Scott A., McElhinny, Stephanie A. Nick, Mieczkowski, Piotr A., Resnick, Michael A., Gordenin, Dmitry A., Kunkel, Thomas A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2010
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955150/
https://ncbi.nlm.nih.gov/pubmed/20876092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010178107
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