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DNA polymerases divide the labor of genome replication
DNA polymerases synthesize DNA in only one direction, but large genomes require RNA priming and bi-directional replication from internal origins. Here we review the physical, chemical and evolutionary constraints underlying these requirements. We then consider the roles of the major eukaryotic repli...
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| Publicado no: | Trends Cell Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993630/ https://ncbi.nlm.nih.gov/pubmed/27262731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2016.04.012 |
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