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Eukaryotic Genome Instability in Light of Asymmetric DNA Replication
The eukaryotic nuclear genome is replicated asymmetrically, with the leading strand replicated continuously and the lagging strand replicated as discontinuous Okazaki fragments that are subsequently joined. Both strands are replicated with high fidelity, but the processes used to achieve high fideli...
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Publicado no: | Crit Rev Biochem Mol Biol |
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Main Authors: | , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922258/ https://ncbi.nlm.nih.gov/pubmed/26822554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2015.1117055 |
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