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Eukaryotic Genome Instability in Light of Asymmetric DNA Replication

The eukaryotic nuclear genome is replicated asymmetrically, with the leading strand replicated continuously and the lagging strand replicated as discontinuous Okazaki fragments that are subsequently joined. Both strands are replicated with high fidelity, but the processes used to achieve high fideli...

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Veröffentlicht in:Crit Rev Biochem Mol Biol
Hauptverfasser: Lujan, Scott A., Williams, Jessica S., Kunkel, Thomas A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922258/
https://ncbi.nlm.nih.gov/pubmed/26822554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2015.1117055
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