Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

Here, we describe a new strategy that allows the rapid and efficient engineering of mono and multispecific trivalent antibodies. By fusing single-domain antibodies from camelid heavy-chain-only immunoglobulins (V(HHs)) to the N-terminus of a human collagen XVIII trimerization domain (TIE(XVIII)) we...

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Publicado no:Sci Rep
Main Authors: Alvarez-Cienfuegos, Ana, Nuñez-Prado, Natalia, Compte, Marta, Cuesta, Angel M., Blanco-Toribio, Ana, Harwood, Seandean Lykke, Villate, Maider, Merino, Nekane, Bonet, Jaume, Navarro, Rocio, Muñoz-Briones, Clara, Sørensen, Karen Marie Juul, Mølgaard, Kasper, Oliva, Baldo, Sanz, Laura, Blanco, Francisco J., Alvarez-Vallina, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921811/
https://ncbi.nlm.nih.gov/pubmed/27345490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28643
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