Generation and characterization of monospecific and bispecific hexavalent trimerbodies

Here, we describe a new class of multivalent and multispecific antibody-based reagents for therapy. The molecules, termed “trimerbodies,” use a modified version of the N-terminal trimerization region of human collagen XVIII noncollagenous 1 domain flanked by two flexible linkers as trimerizing scaff...

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Detalhes bibliográficos
Main Authors: Blanco-Toribio, Ana, Sainz-Pastor, Noelia, Álvarez-Cienfuegos, Ana, Merino, Nekane, Cuesta, Ángel M., Sánchez-Martín, David, Bonet, Jaume, Santos-Valle, Patricia, Sanz, Laura, Oliva, Baldo, Blanco, Francisco J., Álvarez-Vallina, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3564888/
https://ncbi.nlm.nih.gov/pubmed/23221741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.22698
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