Role of Human Organic Cation Transporter 1 (hOCT1) Polymorphisms in Lamivudine (3TC) Uptake and Drug-Drug Interactions

Lamivudine (3TC), a drug used in the treatment of HIV infection, needs to cross the plasma membrane to exert its therapeutic action. Human Organic cation transporter 1 (hOCT1), encoded by the SLC22A1 gene, is the transporter responsible for its uptake into target cells. As SLC22A1 is a highly polymo...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Arimany-Nardi, Cristina, Minuesa, Gerard, Keller, Thorsten, Erkizia, Itziar, Koepsell, Hermann, Martinez-Picado, Javier, Pastor-Anglada, Marçal
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919327/
https://ncbi.nlm.nih.gov/pubmed/27445813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00175
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