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P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp(high) cells and correlates with HIV-1 viral load
OBJECTIVES: To evaluate the role of P-glycoprotein (P-gp) and multidrug-resistant-protein 1 (MRP1) on raltegravir intracellular drug disposition in CD4+ T cells, investigate the effect of HIV-1 infection on P-gp expression and correlate HIV-1 viraemia with P-gp activity in primary CD4+ T cell subset...
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| Publicado no: | J Antimicrob Chemother |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5031918/ https://ncbi.nlm.nih.gov/pubmed/27334660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw215 |
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