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Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?

The proliferative life span of human cells is limited by telomere shortening, but the specific telomeres responsible for determining the onset of senescence have not been adequately determined. We here identify the shortest telomeres by the frequency of signal-free ends after in situ hybridization w...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zou, Ying, Sfeir, Agnel, Gryaznov, Sergei M., Shay, Jerry W., Wright, Woodring E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The American Society for Cell Biology 2004
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC491830/
https://ncbi.nlm.nih.gov/pubmed/15181152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-03-0207
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