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Human Telomeres Maintain Their Overhang Length at Senescence

Normal human cells in culture enter replicative senescence after a finite number of population doublings. The exact molecular mechanisms triggering the growth arrest are poorly understood. A recent report on the disappearance of the G-rich 3′ telomeric overhang in senescent cells led to the hypothes...

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Detalhes bibliográficos
Main Authors: Chai, Weihang, Shay, Jerry W., Wright, Woodring E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061618/
https://ncbi.nlm.nih.gov/pubmed/15743814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.6.2158-2168.2005
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