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Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening
Telomere overhangs are essential for telomere end protection and telomerase extension, but how telomere overhangs are generated is unknown. Leading daughter strands synthesized by conventional semiconservation DNA replication are initially blunt, while lagging daughter strands are shorter by at leas...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371406/ https://ncbi.nlm.nih.gov/pubmed/22661228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.187211.112 |
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