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Altered States of Telomere Deprotection and the Two-Stage Mechanism of Replicative Aging
The molecular distinctions between mortality stages 1 (M1; senescence) and 2 (M2; crisis) of human replicative aging are ill defined. We demonstrate a qualitative difference between telomeric end associations at M1 and the end fusions that produce dicentric chromosomes and breakage-fusion cycles. Kn...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2668373/ https://ncbi.nlm.nih.gov/pubmed/19223460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01569-08 |
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