Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.

Two chimeric genes, PML-RAR alpha and RAR alpha-PML, are formed as a consequence of the acute promyelocytic leukemia (APL)-specific reciprocal translocation of chromosomes 15 and 17 [t(15;17)]. PML-RAR alpha is expressed as a fusion protein. We investigated the organization and expression pattern of...

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Autori principali: Alcalay, M, Zangrilli, D, Fagioli, M, Pandolfi, P P, Mencarelli, A, Lo Coco, F, Biondi, A, Grignani, F, Pelicci, P G
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1992
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC49183/
https://ncbi.nlm.nih.gov/pubmed/1317574
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