Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.

The acute promyelocytic leukaemia (APL) 15;17 translocation generates a PML/RAR alpha chimeric gene which is transcribed as a fusion PML/RAR alpha mRNA. Molecular studies on a large series of APLs revealed great heterogeneity of the PML/RAR alpha transcripts due to: (i) variable breaking of chromoso...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Pandolfi, P P, Alcalay, M, Fagioli, M, Zangrilli, D, Mencarelli, A, Diverio, D, Biondi, A, Lo Coco, F, Rambaldi, A, Grignani, F
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1992
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556589/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1314166/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05185.x
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