Thiolactomycin-based inhibitors of bacterial β-ketoacyl-ACP synthases with in vivo activity

β-Ketoacyl-ACP synthases (KAS) are key enzymes involved in the type II bacterial fatty acid biosynthesis (FASII) pathway and are putative targets for antibacterial discovery. Several natural product KAS inhibitors have previously been reported, including thiolactomycin (TLM), which is produced by No...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Med Chem
Egile Nagusiak: Bommineni, Gopal R., Kapilashrami, Kanishk, Cummings, Jason E., Lu, Yang, Knudson, Susan E., Gu, Chendi, Walker, Stephen G., Slayden, Richard A., Tonge, Peter J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917603/
https://ncbi.nlm.nih.gov/pubmed/27187871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00236
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