Thiolactomycin-based inhibitors of bacterial β-ketoacyl-ACP synthases with in vivo activity

β-Ketoacyl-ACP synthases (KAS) are key enzymes involved in the type II bacterial fatty acid biosynthesis (FASII) pathway and are putative targets for antibacterial discovery. Several natural product KAS inhibitors have previously been reported, including thiolactomycin (TLM), which is produced by No...

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Bibliografske podrobnosti
izdano v:J Med Chem
Main Authors: Bommineni, Gopal R., Kapilashrami, Kanishk, Cummings, Jason E., Lu, Yang, Knudson, Susan E., Gu, Chendi, Walker, Stephen G., Slayden, Richard A., Tonge, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917603/
https://ncbi.nlm.nih.gov/pubmed/27187871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00236
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