Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin

Thiolactomycin (TLM), a natural product thiolactone antibiotic produced by species of Nocardia and Streptomyces, is an inhibitor of the β-ketoacyl-acyl carrier protein synthase (KAS) enzymes in the bacterial fatty acid synthase pathway. Using enzyme kinetics and direct binding studies, TLM has been...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Machutta, Carl A., Bommineni, Gopal R., Luckner, Sylvia R., Kapilashrami, Kanishk, Ruzsicska, Bela, Simmerling, Carlos, Kisker, Caroline, Tonge, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825411/
https://ncbi.nlm.nih.gov/pubmed/20018879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077909
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky