Slow Onset Inhibition of Bacterial β-Ketoacyl-acyl Carrier Protein Synthases by Thiolactomycin

Thiolactomycin (TLM), a natural product thiolactone antibiotic produced by species of Nocardia and Streptomyces, is an inhibitor of the β-ketoacyl-acyl carrier protein synthase (KAS) enzymes in the bacterial fatty acid synthase pathway. Using enzyme kinetics and direct binding studies, TLM has been...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Machutta, Carl A., Bommineni, Gopal R., Luckner, Sylvia R., Kapilashrami, Kanishk, Ruzsicska, Bela, Simmerling, Carlos, Kisker, Caroline, Tonge, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825411/
https://ncbi.nlm.nih.gov/pubmed/20018879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.077909
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados