Gating mechanism of elongating β-ketoacyl-ACP synthases

Carbon-carbon bond forming reactions are essential transformations in natural product biosynthesis. During de novo fatty acid and polyketide biosynthesis, β-ketoacyl-acyl carrier protein (ACP) synthases (KS), catalyze this process via a decarboxylative Claisen-like condensation reaction. KSs must re...

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Udgivet i:Nat Commun
Main Authors: Mindrebo, Jeffrey T., Patel, Ashay, Kim, Woojoo E., Davis, Tony D., Chen, Aochiu, Bartholow, Thomas G., La Clair, James J., McCammon, J. Andrew, Noel, Joseph P., Burkart, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138838/
https://ncbi.nlm.nih.gov/pubmed/32265440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15455-x
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