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Directed evolution of RebH for catalyst-controlled halogenation of indole C–H bonds

RebH variants capable of chlorinating substituted indoles ortho-, meta-, and para- to the indole nitrogen were evolved by directly screening for altered selectivity on deuterium-substituted probe substrates using mass spectrometry. This systematic approach allowed for rapid accumulation of beneficia...

詳細記述

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書誌詳細
出版年:Chem Sci
主要な著者: Andorfer, Mary C., Park, Hyun June, Vergara-Coll, Jaylie, Lewis, Jared C.
フォーマット: Artigo
言語:Inglês
出版事項: Royal Society of Chemistry 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917012/
https://ncbi.nlm.nih.gov/pubmed/27347367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04680g
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