Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model

Adeno-associated virus (AAV) vectors expressing tumoricidal genes injected directly into brain tumors have shown some promise, however, invasive tumor cells are relatively unaffected. Systemic injection of AAV9 vectors provides widespread delivery to the brain and potentially the tumor/microenvironm...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Mol Ther Oncolytics
Autori principali: Crommentuijn, Matheus HW, Kantar, Rami, Noske, David P, Vandertop, W Peter, Badr, Christian E, Würdinger, Thomas, Maguire, Casey A, Tannous, Bakhos A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916948/
https://ncbi.nlm.nih.gov/pubmed/27382645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.17
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi