Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model

Adeno-associated virus (AAV) vectors expressing tumoricidal genes injected directly into brain tumors have shown some promise, however, invasive tumor cells are relatively unaffected. Systemic injection of AAV9 vectors provides widespread delivery to the brain and potentially the tumor/microenvironm...

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Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: Crommentuijn, Matheus HW, Kantar, Rami, Noske, David P, Vandertop, W Peter, Badr, Christian E, Würdinger, Thomas, Maguire, Casey A, Tannous, Bakhos A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916948/
https://ncbi.nlm.nih.gov/pubmed/27382645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.17
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