Intracranial AAV‐sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma

Glioblastoma (GBM) is the most common malignant brain tumor in adults. We designed an adeno‐associated virus (AAV) vector for intracranial delivery of secreted, soluble tumor necrosis factor‐related apoptosis‐inducing ligand (sTRAIL) to GBM tumors in mice and combined it with the TRAIL‐sensitizing c...

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Publicat a:Mol Oncol
Autors principals: Crommentuijn, Matheus H.W., Maguire, Casey A., Niers, Johanna M., Vandertop, W. Peter, Badr, Christian E., Würdinger, Thomas, Tannous, Bakhos A.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826802/
https://ncbi.nlm.nih.gov/pubmed/26708508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.11.011
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