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Design of potent and highly selective inhibitors for human β-secretase 2 (memapsin 1), a target for type 2 diabetes

Design, synthesis and evaluation of very potent and selective β-secretase 2 (memapsin 1, BACE 2) inhibitors are described. The inhibitors were designed specifically to interact with the S2′-site of β-secretase 2 to provide >170 000-fold selectivity over β-secretase (BACE 1) and >15 000-fold se...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Ghosh, Arun K., Reddy, Bhavanam Sekhara, Yen, Yu-Chen, Cárdenas, Emilio L., Rao, Kalapala Venkateswara, Downs, Deborah, Huang, Xiangping, Tang, Jordan, Mesecar, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916918/
https://ncbi.nlm.nih.gov/pubmed/27347366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03718b
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