Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by upregulating glutamate pyruvate transaminase 2 (GPT2) in colorectal cancer (CRC) cells, making them more dependent on glutamine. C...

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Publicado no:Nat Commun
Main Authors: Hao, Yujun, Samuels, Yardena, Li, Qingling, Krokowski, Dawid, Guan, Bo-Jhih, Wang, Chao, Jin, Zhicheng, Dong, Bohan, Cao, Bo, Feng, Xiujing, Xiang, Min, Xu, Claire, Fink, Stephen, Meropol, Neal J., Xu, Yan, Conlon, Ronald A., Markowitz, Sanford, Kinzler, Kenneth W., Velculescu, Victor E., Brunengraber, Henri, Willis, Joseph E., LaFramboise, Thomas, Hatzoglou, Maria, Zhang, Guo-Fang, Vogelstein, Bert, Wang, Zhenghe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915131/
https://ncbi.nlm.nih.gov/pubmed/27321283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11971
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