Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

Cancer cells often require glutamine for growth, thereby distinguishing them from most normal cells. Here we show that PIK3CA mutations reprogram glutamine metabolism by upregulating glutamate pyruvate transaminase 2 (GPT2) in colorectal cancer (CRC) cells, making them more dependent on glutamine. C...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Hao, Yujun, Samuels, Yardena, Li, Qingling, Krokowski, Dawid, Guan, Bo-Jhih, Wang, Chao, Jin, Zhicheng, Dong, Bohan, Cao, Bo, Feng, Xiujing, Xiang, Min, Xu, Claire, Fink, Stephen, Meropol, Neal J., Xu, Yan, Conlon, Ronald A., Markowitz, Sanford, Kinzler, Kenneth W., Velculescu, Victor E., Brunengraber, Henri, Willis, Joseph E., LaFramboise, Thomas, Hatzoglou, Maria, Zhang, Guo-Fang, Vogelstein, Bert, Wang, Zhenghe
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915131/
https://ncbi.nlm.nih.gov/pubmed/27321283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11971
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