5-fluorouracil enhances the anti-tumor activity of the glutaminase inhibitor CB-839 against PIK3CA-mutant colorectal cancers

PIK3CA encodes the p110α catalytic subunit of PI3 kinase and is frequently mutated in human cancers, including ~30% of colorectal cancer (CRC). Oncogenic mutations in PIK3CA render CRCs more dependent on glutamine. Here we report that the glutaminase inhibitor CB-839 preferentially inhibits xenograf...

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Publicado no:Cancer Res
Main Authors: Zhao, Yiqing, Feng, Xiujing, Chen, Yicheng, Selfridge, J. Eva, Gorityala, Shashank, Du, Zhanwen, Wang, Janet M., Hao, Yujun, Cioffi, Gino, Conlon, Ronald A., Barnholtz-Sloan, Jill S., Saltzman, Joel, Krishnamurthi, Smitha S., Vinayak, Shaveta, Veigl, Martina, Xu, Yan, Bajor, David L., Markowitz, Sanford D., Meropol, Neal J., Eads, Jennifer R., Wang, Zhenghe
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642187/
https://ncbi.nlm.nih.gov/pubmed/32907836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-0600
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