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Targeting glutamine metabolism in PIK3CA mutant colorectal cancers
We recently reported that PIK3CA mutant colorectal cancers (CRCs) are addicted to glutamine through up-regulation of glutamate pyruvate transaminase 2 (GPT2). A GPT2 inhibitor suppresses in vivo growth of PIK3CA mutant, but not wild-type, CRCs. This study indicates that targeting glutamine may be an...
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| Publicado no: | Genes Dis |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Chongqing Medical University
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6153462/ https://ncbi.nlm.nih.gov/pubmed/30258894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gendis.2016.09.001 |
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