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PIK3CA in Colorectal Cancer

PIK3CA, the catalytic subunit of PI3K, is mutated in many different tumors, including colorectal cancer (CRC). Mutations of PIK3CA have been reported in 10–20% of CRC, about 80% of mutations found in two hot spots in exon 9 and exon 20. In RAS wild-type CRC, PIK3CA mutations have been associated wit...

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Detalhes bibliográficos
Autor principal: Cathomas, Gieri
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3939771/
https://ncbi.nlm.nih.gov/pubmed/24624362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2014.00035
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