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A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues
Many cancer types reprogram their metabolism to become addicted to glutamine. One of the critical enzymes in the utilization of glutamine in these cells is glutaminase. CB-839 (telaglenastat) is a drug that targets glutaminase that is currently being evaluated in many clinical trials for efficacy in...
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| Publicado no: | J Genet Genomics |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7704934/ https://ncbi.nlm.nih.gov/pubmed/33004309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jgg.2020.06.001 |
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