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Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39

BMP signalling is negatively autoregulated by several genes including SMAD6, Noggin and Gremlin, and autoregulators are possible targets for enhancing BMP signalling in disorders such as fibrosis and pulmonary hypertension. To identify novel negative regulators of BMP signalling, we used siRNA scree...

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Pubblicato in:Sci Rep
Autori principali: Faherty, Noel, Benson, Matthew, Sharma, Eshita, Lee, Angela, Howarth, Alison, Lockstone, Helen, Ebner, Daniel, Bhattacharya, Shoumo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914931/
https://ncbi.nlm.nih.gov/pubmed/27324164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28210
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