Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay

Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are frequently observed in lung adenocarcinoma (LUAD). We have previously shown that RBM10 enhances exon skipping of its target genes, including its paralog RBM5. Here, we report that RBM10 negatively regulates its own m...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Sun, Yue, Bao, Yufang, Han, Wenjian, Song, Fan, Shen, Xianfeng, Zhao, Jiawei, Zuo, Ji, Saffen, David, Chen, Wei, Wang, Zefeng, You, Xintian, Wang, Yongbo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737846/
https://ncbi.nlm.nih.gov/pubmed/28586478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx508
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