Functional analysis reveals that RBM10 mutations contribute to lung adenocarcinoma pathogenesis by deregulating splicing

RBM10 is an RNA splicing regulator that is frequently mutated in lung adenocarcinoma (LUAD) and has recently been proposed to be a cancer gene. How RBM10 mutations observed in LUAD affect its normal functions, however, remains largely unknown. Here integrative analysis of RBM10 mutation and RNA expr...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhao, Jiawei, Sun, Yue, Huang, Yin, Song, Fan, Huang, Zengshu, Bao, Yufang, Zuo, Ji, Saffen, David, Shao, Zhen, Liu, Wen, Wang, Yongbo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238425/
https://ncbi.nlm.nih.gov/pubmed/28091594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40488
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