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Negative autoregulation of BMP dependent transcription by SIN3B splicing reveals a role for RBM39

BMP signalling is negatively autoregulated by several genes including SMAD6, Noggin and Gremlin, and autoregulators are possible targets for enhancing BMP signalling in disorders such as fibrosis and pulmonary hypertension. To identify novel negative regulators of BMP signalling, we used siRNA scree...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Faherty, Noel, Benson, Matthew, Sharma, Eshita, Lee, Angela, Howarth, Alison, Lockstone, Helen, Ebner, Daniel, Bhattacharya, Shoumo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914931/
https://ncbi.nlm.nih.gov/pubmed/27324164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28210
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