Phosphoinositide 3-Kinase Delta Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity

The C-type lectin receptor (CLR) Dectin-2 can trigger the leukotriene C(4) synthase (LTC(4)S)-dependent generation of cysteinyl leukotrienes (cys-LTs) and the CARD9- and NF-κB-dependent generation of cytokines, such as IL-23, IL-6, and TNF-α, to promote Th2 and Th17 immunity, respectively. Dectin-2...

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Bibliographic Details
Published in:J Immunol
Main Authors: Lee, Min Jung, Yoshimoto, Eri, Saijo, Shinobu, Iwakura, Yoichiro, Lin, Xin, Katz, Howard R., Kanaoka, Yoshihide, Barrett, Nora A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912906/
https://ncbi.nlm.nih.gov/pubmed/27194783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502485
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