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Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis

Il1rn(−/−) mice spontaneously develop arthritis and aortitis by an autoimmune mechanism and also develop dermatitis by an autoinflammatory mechanism. Here, we show that Rag2(−/−)Il1rn(−/−) mice develop spontaneous colitis with high mortality, making a contrast to the suppression of arthritis in thes...

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Detalhes bibliográficos
Main Authors: Akitsu, Aoi, Kakuta, Shigeru, Saijo, Shinobu, Iwakura, Yoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Association for Laboratory Animal Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160983/
https://ncbi.nlm.nih.gov/pubmed/24770649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.63.235
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