TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

IL-1 receptor antagonist–deficient (IL-1Ra(–/–)) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient IL-1Ra(–/–) mice did not develop arthritis, and transfer of IL-1Ra(–/–) T cells induced arthritis in nu/nu...

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Detalhes bibliográficos
Main Authors: Horai, Reiko, Nakajima, Akiko, Habiro, Katsuyoshi, Kotani, Motoko, Nakae, Susumu, Matsuki, Taizo, Nambu, Aya, Saijo, Shinobu, Kotaki, Hayato, Sudo, Katsuko, Okahara, Akihiko, Tanioka, Hidetoshi, Ikuse, Toshimi, Ishii, Naoto, Schwartzberg, Pamela L., Abe, Ryo, Iwakura, Yoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529278/
https://ncbi.nlm.nih.gov/pubmed/15578092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420742
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