TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

IL-1 receptor antagonist–deficient (IL-1Ra(–/–)) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell–deficient IL-1Ra(–/–) mice did not develop arthritis, and transfer of IL-1Ra(–/–) T cells induced arthritis in nu/nu...

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Pubblicato in:	J Clin Invest
Autori principali:	Horai, Reiko, Nakajima, Akiko, Habiro, Katsuyoshi, Kotani, Motoko, Nakae, Susumu, Matsuki, Taizo, Nambu, Aya, Saijo, Shinobu, Kotaki, Hayato, Sudo, Katsuko, Okahara, Akihiko, Tanioka, Hidetoshi, Ikuse, Toshimi, Ishii, Naoto, Schwartzberg, Pamela L., Abe, Ryo, Iwakura, Yoichiro
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 2004
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC529278/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15578092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI20742
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