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Rag2-deficient IL-1 Receptor Antagonist-deficient Mice Are a Novel Colitis Model in Which Innate Lymphoid Cell-derived IL-17 Is Involved in the Pathogenesis
Il1rn(−/−) mice spontaneously develop arthritis and aortitis by an autoimmune mechanism and also develop dermatitis by an autoinflammatory mechanism. Here, we show that Rag2(−/−)Il1rn(−/−) mice develop spontaneous colitis with high mortality, making a contrast to the suppression of arthritis in thes...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Japanese Association for Laboratory Animal Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4160983/ https://ncbi.nlm.nih.gov/pubmed/24770649 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1538/expanim.63.235 |
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