Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

Constitutive androstane receptor (CAR) regulates hepatic xenobiotic and energy metabolism, as well as promotes cell growth and hepatocarcinogenesis. Berberine is an ancient multipotent alkaloid drug which derived from Coptis chinensis plants. Here we report that berberine is able to be cellular upta...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhang, Lei, Miao, Xiao-Jie, Wang, Xin, Pan, Hai-Hui, Li, Pu, Ren, Hong, Jia, Yong-Rui, Lu, Chuang, Wang, Hong-Bing, Yuan, Lan, Zhang, Guo-Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911599/
https://ncbi.nlm.nih.gov/pubmed/27311637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28116
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