Phosphorylation of Ca(v)1.2 on S1928 uncouples the L‐type Ca(2+) channel from the β(2) adrenergic receptor

Agonist‐triggered downregulation of β‐adrenergic receptors (ARs) constitutes vital negative feedback to prevent cellular overexcitation. Here, we report a novel downregulation of β(2) AR signaling highly specific for Ca(v)1.2. We find that β(2)‐AR binding to Ca(v)1.2 residues 1923–1942 is required f...

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Библиографические подробности
Опубликовано в: :EMBO J
Главные авторы: Patriarchi, Tommaso, Qian, Hai, Di Biase, Valentina, Malik, Zulfiquar A, Chowdhury, Dhrubajyoti, Price, Jennifer L, Hammes, Erik A, Buonarati, Olivia R, Westenbroek, Ruth E, Catterall, William A, Hofmann, Franz, Xiang, Yang K, Murphy, Geoffrey G, Chen, Chao‐Ye, Navedo, Manuel F, Hell, Johannes W
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910527/
https://ncbi.nlm.nih.gov/pubmed/27103070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593409
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