Ser(1928) phosphorylation by PKA stimulates the L-type Ca(2+) channel Ca(V)1.2 and vasoconstriction during acute hyperglycemia and diabetes

Hypercontractility of arterial myocytes and enhanced vascular tone during diabetes are, in part, attributed to the effects of increased glucose (hyperglycemia) on L-type Ca(V)1.2 channels. In murine arterial myocytes, kinase-dependent mechanisms mediate the increase in Ca(V)1.2 activity in response...

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Publicado no:Sci Signal
Main Authors: Nystoriak, Matthew A., Nieves-Cintrón, Madeline, Patriarchi, Tommaso, Buonarati, Olivia R., Prada, Maria Paz, Morotti, Stefano, Grandi, Eleonora, Fernandes, Julia Dos Santos, Forbush, Katherine, Hofmann, Franz, Sasse, Kent C., Scott, John D., Ward, Sean M., Hell, Johannes W., Navedo, Manuel F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297430/
https://ncbi.nlm.nih.gov/pubmed/28119464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf9647
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