A G(s)-coupled purinergic receptor boosts Ca(2+) influx and vascular contractility during diabetic hyperglycemia

Elevated glucose increases vascular reactivity by promoting L-type Ca(V)1.2 channel (LTCC) activity by protein kinase A (PKA). Yet, how glucose activates PKA is unknown. We hypothesized that a G(s)-coupled P2Y receptor is an upstream activator of PKA mediating LTCC potentiation during diabetic hyper...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Prada, Maria Paz, Syed, Arsalan U, Buonarati, Olivia R, Reddy, Gopireddy R, Nystoriak, Matthew A, Ghosh, Debapriya, Simó, Sergi, Sato, Daisuke, Sasse, Kent C, Ward, Sean M, Santana, Luis F, Xiang, Yang K, Hell, Johannes W, Nieves-Cintrón, Madeline, Navedo, Manuel F
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6397001/
https://ncbi.nlm.nih.gov/pubmed/30821687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42214
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