Phosphorylation of Ca(v)1.2 on S1928 uncouples the L‐type Ca(2+) channel from the β(2) adrenergic receptor

Agonist‐triggered downregulation of β‐adrenergic receptors (ARs) constitutes vital negative feedback to prevent cellular overexcitation. Here, we report a novel downregulation of β(2) AR signaling highly specific for Ca(v)1.2. We find that β(2)‐AR binding to Ca(v)1.2 residues 1923–1942 is required f...

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Pubblicato in:EMBO J
Autori principali: Patriarchi, Tommaso, Qian, Hai, Di Biase, Valentina, Malik, Zulfiquar A, Chowdhury, Dhrubajyoti, Price, Jennifer L, Hammes, Erik A, Buonarati, Olivia R, Westenbroek, Ruth E, Catterall, William A, Hofmann, Franz, Xiang, Yang K, Murphy, Geoffrey G, Chen, Chao‐Ye, Navedo, Manuel F, Hell, Johannes W
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910527/
https://ncbi.nlm.nih.gov/pubmed/27103070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593409
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