Phosphorylation of Ca(v)1.2 on S1928 uncouples the L‐type Ca(2+) channel from the β(2) adrenergic receptor

Agonist‐triggered downregulation of β‐adrenergic receptors (ARs) constitutes vital negative feedback to prevent cellular overexcitation. Here, we report a novel downregulation of β(2) AR signaling highly specific for Ca(v)1.2. We find that β(2)‐AR binding to Ca(v)1.2 residues 1923–1942 is required f...

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Detaylı Bibliyografya
Yayımlandı:EMBO J
Asıl Yazarlar: Patriarchi, Tommaso, Qian, Hai, Di Biase, Valentina, Malik, Zulfiquar A, Chowdhury, Dhrubajyoti, Price, Jennifer L, Hammes, Erik A, Buonarati, Olivia R, Westenbroek, Ruth E, Catterall, William A, Hofmann, Franz, Xiang, Yang K, Murphy, Geoffrey G, Chen, Chao‐Ye, Navedo, Manuel F, Hell, Johannes W
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4910527/
https://ncbi.nlm.nih.gov/pubmed/27103070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593409
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