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Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice
Mutations or deletions of the maternal allele of the UBE3A gene cause Angelman syndrome (AS), a severe neurodevelopmental disorder. The paternal UBE3A/Ube3a allele becomes epigenetically silenced in most neurons during postnatal development in humans and mice; hence, loss of the maternal allele larg...
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| Published in: | Sci Rep |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4910164/ https://ncbi.nlm.nih.gov/pubmed/27306933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28238 |
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