Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice

Angelman syndrome (AS) is a neurodevelopmental disorder in which epilepsy is common (~90%) and often refractory to antiepileptics. AS is caused by mutation of the maternal allele encoding the ubiquitin protein ligase E3A (UBE3A), but it is unclear how this genetic insult confers vulnerability to sei...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Gu, Bin, Carstens, Kelly E., Judson, Matthew C., Dalton, Katherine A., Rougié, Marie, Clark, Ellen P., Dudek, Serena M., Philpot, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Concise Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307939/
https://ncbi.nlm.nih.gov/pubmed/30352049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120816
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