Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice

Angelman syndrome (AS) is a neurodevelopmental disorder in which epilepsy is common (~90%) and often refractory to antiepileptics. AS is caused by mutation of the maternal allele encoding the ubiquitin protein ligase E3A (UBE3A), but it is unclear how this genetic insult confers vulnerability to sei...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Gu, Bin, Carstens, Kelly E., Judson, Matthew C., Dalton, Katherine A., Rougié, Marie, Clark, Ellen P., Dudek, Serena M., Philpot, Benjamin D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2018
Konular:
Concise Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307939/
https://ncbi.nlm.nih.gov/pubmed/30352049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120816
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