Ube3a reinstatement mitigates epileptogenesis in Angelman syndrome model mice

Angelman syndrome (AS) is a neurodevelopmental disorder in which epilepsy is common (~90%) and often refractory to antiepileptics. AS is caused by mutation of the maternal allele encoding the ubiquitin protein ligase E3A (UBE3A), but it is unclear how this genetic insult confers vulnerability to sei...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Clin Invest
Main Authors: Gu, Bin, Carstens, Kelly E., Judson, Matthew C., Dalton, Katherine A., Rougié, Marie, Clark, Ellen P., Dudek, Serena M., Philpot, Benjamin D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Concise Communication
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6307939/
https://ncbi.nlm.nih.gov/pubmed/30352049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI120816
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