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Genotype-guided tacrolimus dosing in African American kidney transplant recipients
Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5 enzyme is controlled by several alleles including CYP3A5*1, CYP3A5*3, CYP3A5*6 and CYP3A5*7. African Americans (AA) have on average higher tacrolimus dose requirements than Caucasians; however, some have requirements s...
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| Publicado no: | Pharmacogenomics J |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4909584/ https://ncbi.nlm.nih.gov/pubmed/26667830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2015.87 |
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